__________ is the diminished response to same dosage of a drug, either developed slowly or acutely.

__________ is the diminished response to same dosage of a drug, either developed slowly or acutely.

• A. Acquired resistance
• B. Sensitization
• C. Tolerance
• D. Potentiation

Answer: (C)

Tolerance is a diminished response to the same dose of a drug after repeated exposure. It can develop slowly through pharmacodynamic changes, such as receptor downregulation or desensitization, or acutely as tachyphylaxis. This differs from acquired resistance (often seen in microbes or cancer cells becoming unresponsive to a drug), sensitization (an increased response with exposure), and potentiation (one drug increasing the effect of another without itself becoming less effective).

Tolerance is a diminished response to the same dose of a drug after repeated exposure. It can develop slowly through pharmacodynamic changes, such as receptor downregulation or desensitization, or acutely as tachyphylaxis.

This differs from acquired resistance (often seen in microbes or cancer cells becoming unresponsive to a drug), sensitization (an increased response with exposure), and potentiation (one drug increasing the effect of another without itself becoming less effective).